Exposure to synthetic and naturally occurring chemicals can affect important endocrine pathways and induce toxic responses. Authors from a variety of scientific disciplines contributed to the CAST paper, which provides an analysis of multiple, widely reported issues, such as altered reproductive development and increased incidences of cancer. Chair: Stephen H. Safe, Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station. IP16, July 2000, 16 pp., FREE. Available online (www.cast-science.org) AND in print (515-292-2125; fee for shipping/handling).